Academic Research on Gene and Cell Therapy in The Netherlands

Prof. Dr. V. W. van Beusechem

Department of Medical Oncology (Cancer Center Amsterdam)

Alternative splicing in lung cancer, and generation and validation of oncolytic adenoviruses based on screening data. 

Group members: T. Brachtlová, J. Li, I. Milenova, I. va der Meulen-Muileman

Key words: Oncolytic adenoviruses; Therapeutic target discovery; RNA interference; Drug development

https://research.vumc.nl/en/persons/victor-w-van-beusechem; http://www.orca-therapeutics.nl/

Prof. Dr. V. M. Christoffels

Department of Experimental Cardiology (Heart Failure Research Center)

Development of adeno-associated virus-based gene therapy for restoring heart rhythm .

Group members:

Key words: Basic research; Translational research; Viral vectors; Cell engineering; Gene replacement.

http://www.hartfaalcentrum.nl/ 



Dr. B. G. van den Hoogen

Department of Viroscience

Developing the Newcastle Disease virus for use in viro-immuno-therapy for patients with pancreatic cancer. 

Group members:

Key words: Basic research; Translational research; Oncolytic viruses; Viral vectors; Immunity.

https://www.erasmusmc.nl/viroscience/research/researchers/vandenhoogen/  

Dr. J. de Vrij

Department of Neurosurgery

Exploring extracellular vesicles (exosomes) as a tool to improve (gene) therapy or diagnosis of cancer

Group members: M. Lamfers, E. Stavrakaki, L. Vogelezang

Key words: Gene Therapy; Oncolytic viruses; Exosomes; Extracellular vesicle; Cancer.

http://www.exovectory.com  



Dr. M. H. M. Heemskerk

Department of Hematology

Development and implementation of T cell receptor gene therapy for hematological malignancies and solid tumors 

Key words: Translational research; Viral vectors; Immunity; Gene replacement. 

Prof. Dr. R. C. Hoeben

Department of Cell and Chemical Biology

Development of virus-derived tools for gene and stem-cell therapy. We evaluate our vectors in collaboration with clinically oriented groups in a variety of disease models.

Group members: Dr. V. Kemp

Key words: Basic research; Translational research; Oncolytic viruses; Viral vectors; Immunity; Regenerative medicine; Cell engineering; Genome editing/repair; Gene replacement.

https://ccb.lumc.nl/virus-cell-interactions-129



Dr. J. Theys

Department of Prescision Medicine M-Lab

Development of novel and innovative therapies for cancer treatment and vaccination based on the use of prokaryotic living medicine vectors.

Group members: Prof. Dr. P. Lambin, Dr. L. Dubois, Dr. T. Bailey, Dr. A. Kubiak, Dr. A. Mowday, N. Lieuwes, R. Biemans.

Key words: Translational research; Living medicine; prokaryotic vectors; cancer; vaccination.

https://precisionmedicinemaastricht.eu



Dr. R. W. J. Collin

Department of Human Genetics

Development of therapeutic molecular strategies to correct genetic defects causing inherited retinal diseases. 

Group members: Dr. I. Vázquez Domínguez, L. Duijkers, T. Tomkiewicz, M. Peeters, N. Suárez Herrera

Key words: Basic research; Translational research; Viral vectors; Cell engineering; Genome editing/repair; Gene replacement; RNA therapeutics; inherited retinal diseases.

http://www.collin-garanto-lab.com 

Dr. A. Garanto

Department of Pediatrics (Amalia Children’s Hospital) & Department of Human Genetics

Development of novel therapeutic strategies at DNA and RNA level to correct genetic defects causing neurometabolic or inherited retinal diseases.

Group members: Dr. I. Vázquez Domínguez, A. Hoogendoorn, L. Duijkers, T.Tomkiewicz, N. Suárez Herrera, I. Schuurmans

Key words: Basic research; Translational research; Viral vectors; Cell engineering; Genome editing/repair; Gene replacement; RNA therapeutics; inherited retinal diseases; inherited neurometabolic diseases.

Dr. D. G. Wansink

Department of Cell Biology

Development of improved delivery strategies (in vitro and in vivo) for therapeutic antisense oligonucleotides in the context of Myotonic dystrophy type 1. 

Group members:

Key words: Translational research; RNA therapeutics.



Prof. Dr. C. A. F. F. Daemen

Department of Medical Microbiology

Development of strategies for the immunotherapeutic treatment of virus-induced cancer. 

Group members:

Key words: Basic research; Translational research; Viral vectors; Vaccines; Immunity.

https://www.umcg.nl/EN/corporate/Departments/Medical_Microbiology/Research/Tumor_Viruses_And_Cancer_Immunotherapy/Paginas/default.aspx

Prof. Dr. H.J. Haisma

Department of Chemical and Pharmaceutical Biology

Enhancing the efficacy and specificity of targeted genome editing with CRISPR/CAS9.

Group members: C. Cheng, D. Cheng, P. Ettema, F.J. Dekker

Key words: CRISPR/CAS9, genome editing

https://www.rug.nl/research/grip/cpb/

https://www.rug.nl/staff/h.j.haisma/research



Dr. Ing. L. A. Vonk

Department of Orthopaedics

Biological regeneration of joint tissues; the development of (one-stage) cell or cell-based therapies to repair cartilage and meniscus tissue and restore joint homeostasis. 

Group members:

Key words: Translational research; Exosomes; Regenerative medicine; Cell therapy.



Prof. Dr. R. Masereeuw

Department of Pharmacology

One of the things we work on is the evaluation of new therapies for genetic kidney diseases like cystinosis. We use human proximal tubular cells with different gene mutations to study the molecular pathways affected and see how we can use gene editing to restore the gene defect. 

Group members:

Key words: Translational research; Regenerative medicine; Cell engineering; Genome editing/repair; Gene replacement.

Prof. Dr. E. Mastrobattista

Department of Pharmaceutics

Design and pre-clinical testing of tailor-made drug delivery systems for site-specific, time- and/or rate-controlled delivery of small drugs, therapeutic proteins, nucleic acids, and antigens for use in diseases such as cancer, inflammation and infectious diseases. 

Group members:

Key words: Basic research; Translational research; Vaccines; Genome editing/repair; Synthetic vectors; RNA therapeutics.







If you want your group to be listed, please send us an email to NVGCTherapy”at”gmail.com with the information in the format presented above.