Academic Research on Gene and Cell Therapy in The Netherlands

Prof. Dr. V. W. van Beusechem

Department of Medical Oncology (Cancer Center Amsterdam)

Alternative splicing in lung cancer, and generation and validation of oncolytic adenoviruses based on screening data. 

Group members: T. Brachtlová

Key words: Translational research; Exosomes; Oncolytic viruses; Immunity; RNA therapeutics

Prof. Dr. V. M. Christoffels

Department of Experimental Cardiology (Heart Failure Research Center)

Development of adeno-associated virus-based gene therapy for restoring heart rhythm .

Group members:

Key words: Basic research; Translational research; Viral vectors; Cell engineering; Gene replacement.

http://www.hartfaalcentrum.nl/ 



Dr. B. G. van den Hoogen

Department of Viroscience

Developing the Newcastle Disease virus for use in viro-immuno-therapy for patients with pancreatic cancer. 

Group members:

Key words: Basic research; Translational research; Oncolytic viruses; Viral vectors; Immunity.

https://www.erasmusmc.nl/viroscience/research/researchers/vandenhoogen/  



Dr. M. H. M. Heemskerk

Department of Hematology

Development and implementation of T cell receptor gene therapy for hematological malignancies and solid tumors 

Key words: Translational research; Viral vectors; Immunity; Gene replacement. 

Prof. Dr. R. C. Hoeben

Department of Cell and Chemical Biology

Development of virus-derived tools for gene and stem-cell therapy. We evaluate our vectors in collaboration with clinically oriented groups in a variety of disease models.

Group members: Dr. V. Kemp

Key words: Basic research; Translational research; Oncolytic viruses; Viral vectors; Immunity; Regenerative medicine; Cell engineering; Genome editing/repair; Gene replacement.

https://ccb.lumc.nl/virus-cell-interactions-129



Dr. R. W. J. Collin

Department of Human Genetics

Development of therapeutic molecular strategies to correct genetic defects causing inherited retinal diseases. 

Group members: Dr. Irene Vázquez Domínguez, Lonneke Duijkers, Tomasz Tomkiewicz, Manon Peeters, Nuria Suárez Herrera

Key words: Basic research; Translational research; Viral vectors; Cell engineering; Genome editing/repair; Gene replacement; RNA therapeutics.

http://www.collin-garanto-lab.com 

Dr. A. Garanto

Department of Pediatrics (Amalia Children’s Hospital) & Department of Human Genetics

Development of novel therapeutic strategies at DNA and RNA level to correct genetic defects causing neurometabolic or inherited retinal diseases.

Group members: Dr. Irene Vázquez Domínguez, Anita Hoogendoorn, Lonneke Duijkers, Tomasz Tomkiewicz, Nuria Suárez Herrera, Imke Schuurmans

Key words: Basic research; Translational research; Viral vectors; Cell engineering; Genome editing/repair; Gene replacement; RNA therapeutics.

Dr. D. G. Wansink

Department of Cell Biology

Development of improved delivery strategies (in vitro and in vivo) for therapeutic antisense oligonucleotides in the context of Myotonic dystrophy type 1. 

Group members:

Key words: Translational research; RNA therapeutics.



Prof. Dr. C. A. F. F. Daemen

Department of Medical Microbiology

Development of strategies for the immunotherapeutic treatment of virus-induced cancer. 

Group members:

Key words: Basic research; Translational research; Viral vectors; Vaccines; Immunity.



Dr. Ing. L. A. Vonk

Department of Orthopaedics

Biological regeneration of joint tissues; the development of (one-stage) cell or cell-based therapies to repair cartilage and meniscus tissue and restore joint homeostasis. 

Group members:

Key words: Translational research; Exosomes; Regenerative medicine; Cell therapy.



Prof. Dr. R. Masereeuw

Department of Pharmacology

One of the things we work on is the evaluation of new therapies for genetic kidney diseases like cystinosis. We use human proximal tubular cells with different gene mutations to study the molecular pathways affected and see how we can use gene editing to restore the gene defect. 

Group members:

Key words: Translational research; Regenerative medicine; Cell engineering; Genome editing/repair; Gene replacement.

Prof. Dr. E. Mastrobattista

Department of Pharmaceutics

Design and pre-clinical testing of tailor-made drug delivery systems for site-specific, time- and/or rate-controlled delivery of small drugs, therapeutic proteins, nucleic acids, and antigens for use in diseases such as cancer, inflammation and infectious diseases. 

Group members:

Key words: Basic research; Translational research; Vaccines; Genome editing/repair; Synthetic vectors; RNA therapeutics.